FAK phosphorylation at Tyr-925 regulates cross-talk between focal adhesion turnover and cell protrusion

摘要

FAK plays a key role in the regulation of cell migration. The authors show that the phosphorylation status of FAK at Tyr-925 is involved in FA turnover, formation of FAs, and increase in cell edge protrusion, together with activation of the p130CAS/Rac1 signaling pathway.